The inhibition of PINK1/Drp1-mediated mitophagy by hyperglycemia leads to impaired osteoblastogenesis in diabetes
Summary: Impaired bone quality and increased fracture risk are cardinal features of the skeleton Boxer in diabetes mellitus.Hyperglycemia-induced oxidative stress is proposed as a potential underlying mechanism, but the precise pathogenic mechanism remains incompletely understood.In this investigation, osteoblasts under high glucose exhibited heigh